In his book “Willful Ignorance: The Mismeasurement of Uncertainty”, Herbert I. Weisberg notes: “Medical research is often held up as the paragon of statistical research methodology. Evidence-based medicine, based on randomized clinical trials, can provide proof of the effectiveness and safety of various drugs and other therapies.” (1)  He goes on to note that clinical practitioners, who’s judgement is informed by evidence-based data, are finding little in the research that is useful. Continue reading →